इतो मृत्युरितो व्याधिरितो विपदितो जरा।

इतो मृत्युरितो व्याधिरितो विपदितो जरा।

चतुरङ्ग तुल्यबला हन्ति लोकमनित्यता॥

महाभारते शान्तिपर्वे २०५-४

ito mṛtyurito vyādhirito vipadito jarā|

caturaṅga tulyabalā hanti lokamanityatā||

mahābhārate śāntiparve 205-4

The world and its occupants are attacked by the army consisting of four equally powerful wings ( like the chaturanga force in formal wars ).. the combined attack is by the force of uncertainty and impermanence..

The four limbs of the attackhing army are

Death, Disease, Dangers and accidents and Old age

( All these strengthen one another and jointly and severally add to the state of perilous uncertainty )

This statement occurs in Mahabharatham, but reveals a perennial truth.